| Entry |
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| Name |
Notch proteolytic activation
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| Definition |
NOTCH -- ADAM17 >> (PSEN+PSENEN+NCSTN+APH1) -> NICD |
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| Expanded |
(4851,4853,4854,4855) -- 6868 >> ((5663,5664)+55851+23385+(51107,83464)) -> C22528 |
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| Class |
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| Type |
Reference
|
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| Pathway |
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| Gene |
| 4851 | NOTCH1; notch receptor 1 |
| 4853 | NOTCH2; notch receptor 2 |
| 4854 | NOTCH3; notch receptor 3 |
| 4855 | NOTCH4; notch receptor 4 |
| 6868 | ADAM17; ADAM metallopeptidase domain 17 |
| 55851 | PSENEN; presenilin enhancer, gamma-secretase subunit |
| 51107 | APH1A; aph-1 homolog A, gamma-secretase subunit |
| 83464 | APH1B; aph-1 homolog B, gamma-secretase subunit |
|
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| Metabolite |
| C22528 | Notch intracellular domain |
|
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| Reference |
|
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| Authors |
Ranganathan P, Weaver KL, Capobianco AJ |
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| Title |
Notch signalling in solid tumours: a little bit of everything but not all the time. |
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| Journal |
|
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| Reference |
|
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| Authors |
Kopan R, Ilagan MX |
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| Title |
The canonical Notch signaling pathway: unfolding the activation mechanism. |
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| Journal |
|
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| Reference |
|
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| Authors |
Hori K, Sen A, Artavanis-Tsakonas S |
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| Title |
Notch signaling at a glance. |
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| Journal |
|
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| Reference |
|
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| Authors |
Bray SJ |
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| Title |
Notch signalling: a simple pathway becomes complex. |
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| Journal |
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