| Entry |
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| Name |
Salmonella SopE to Inflammasome signaling pathway
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| Definition |
SopE -> RAC1 -> CASP1 -> (IL1B,IL18) |
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| Expanded |
K13741 -> 5879 -> 834 -> (3553,3606) |
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| Class |
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| Type |
Pathogen
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| Pathway |
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| Disease |
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| Gene |
| 5879 | RAC1; Rac family small GTPase 1 |
| 3553 | IL1B; interleukin 1 beta |
| 3606 | IL18; interleukin 18 |
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| Perturbant |
| K13741 (SopE) | sopE; guanine nucleotide exchange factor SopE |
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| Reference |
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| Authors |
Muller AJ, Hoffmann C, Galle M, Van Den Broeke A, Heikenwalder M, Falter L, Misselwitz B, Kremer M, Beyaert R, Hardt WD |
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| Title |
The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. |
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| Journal |
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| Reference |
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| Authors |
Hoffmann C, Galle M, Dilling S, Kappeli R, Muller AJ, Songhet P, Beyaert R, Hardt WD |
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| Title |
In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin. |
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| Journal |
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