KEGG NETWORK: N00879

NETWORK: N00879

Entry

N00879                      Network

Name

PROK-PRKR-Gi-ERK signaling pathway

Definition

PROK1/2 -> PROKR1/2 -> GNAI -> ERK

Expanded

(84432,60675) -> (10887,128674) -> (2770,2771,2773) -> (5594,5595)

Class

nt06325 Hormone/cytokine signaling

Type

Reference

Gene

84432

PROK1; prokineticin 1

60675

PROK2; prokineticin 2

10887

PROKR1; prokineticin receptor 1

128674

PROKR2; prokineticin receptor 2

2770	GNAI1; G protein subunit alpha i1

2771	GNAI2; G protein subunit alpha i2

2773	GNAI3; G protein subunit alpha i3

5594	MAPK1; mitogen-activated protein kinase 1

5595	MAPK3; mitogen-activated protein kinase 3

Reference

PMID:18440852

Authors

Ngan ES, Tam PK

Title

Prokineticin-signaling pathway.

Journal

Int J Biochem Cell Biol 40:1679-84 (2008)
DOI:10.1016/j.biocel.2008.03.010

Reference

PMID:11886876

Authors

Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY

Title

Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.

Journal

J Biol Chem 277:19276-80 (2002)
DOI:10.1074/jbc.M202139200

Reference

PMID:17200460

Authors

Zhou QY

Title

The prokineticins: a novel pair of regulatory peptides.

Journal

Mol Interv 6:330-8 (2006)
DOI:10.1124/mi.6.6.6

Reference

PMID:15772293

Authors

Chen J, Kuei C, Sutton S, Wilson S, Yu J, Kamme F, Mazur C, Lovenberg T, Liu C

Title

Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.

Journal

Mol Pharmacol 67:2070-6 (2005)
DOI:10.1124/mol.105.011619

All links

Gene (9)   
   KEGG GENES (9)   
Literature (4)   
   PubMed (4)   
All databases (13)   

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