KEGG NETWORK: N00407

NETWORK: N00407

Entry

N00407                      Network

Name

HCMV UL33 to GNAQ-PLCB/G-calcineurin signaling pathway

Definition

UL33 -> (GNAQ,GNA11)

Expanded

K22782 -> (2776,2767)

Class

nt06533 Chemokine signaling
nt06167 Human cytomegalovirus (HCMV)

Type

Pathogen

Pathway

hsa05163

Human cytomegalovirus infection

Disease

H00368

Cytomegalovirus infection

Gene

2776	GNAQ; G protein subunit alpha q

2767	GNA11; G protein subunit alpha 11

Perturbant

K22782 (UL33)

UL33; Cytomegalovirus G-protein coupled receptor UL33

Reference

PMID:16406796

Authors

van Cleef KW, Smit MJ, Bruggeman CA, Vink C

Title

Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines.

Journal

J Clin Virol 35:343-8 (2006)
DOI:10.1016/j.jcv.2005.10.013

Reference

PMID:14522997

Authors

Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ

Title

Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.

Journal

J Biol Chem 278:50010-23 (2003)
DOI:10.1074/jbc.M306530200

Reference

PMID:15172446

Authors

Michelson S

Title

Consequences of human cytomegalovirus mimicry.

Journal

Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002

Reference

PMID:10702716

Authors

Vink C, Beisser PS, Bruggeman CA

Title

Molecular mimicry by cytomegaloviruses. Function of cytomegalovirus-encoded homologues of G protein-coupled receptors, MHC class I heavy chains and chemokines.

Journal

Intervirology 42:342-9 (1999)
DOI:10.1159/000053970

Reference

PMID:15990176

Authors

Couty JP, Gershengorn MC

Title

G-protein-coupled receptors encoded by human herpesviruses.

Journal

Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Literature (5)   
   PubMed (5)   
All databases (9)   

Download RDF

DBGET integrated database retrieval system