KEGG NETWORK: N00282

NETWORK: N00282

Entry

N00282                      Network

Name

EREG-EGFR-PI3K signaling pathway

Definition

EREG -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K

Expanded

2069 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)

Class

nt06260 Colorectal cancer
nt06214 PI3K signaling (cancer)

Type

Reference

Pathway

hsa04151

PI3K-Akt signaling pathway

Gene

2069	EREG; epiregulin

1956	EGFR; epidermal growth factor receptor

5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

207	AKT1; AKT serine/threonine kinase 1

208	AKT2; AKT serine/threonine kinase 2

10000

AKT3; AKT serine/threonine kinase 3

2475	MTOR; mechanistic target of rapamycin kinase

6198	RPS6KB1; ribosomal protein S6 kinase B1

6199	RPS6KB2; ribosomal protein S6 kinase B2

Metabolite

C05981

Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:14967450

Authors

Marmor MD, Skaria KB, Yarden Y.

Title

Signal transduction and oncogenesis by ErbB/HER receptors.

Journal

Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002

Reference

PMID:17000658

Authors

Scaltriti M, Baselga J.

Title

The epidermal growth factor receptor pathway: a model for targeted therapy.

Journal

Clin Cancer Res 12:5268-72 (2006)
DOI:10.1158/1078-0432.CCR-05-1554

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (11)   
   KEGG GENES (11)   
Literature (2)   
   PubMed (2)   
All databases (15)   

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