KEGG NETWORK: N00149

NETWORK: N00149

Entry

N00149                      Network

Name

TLR3-IRF3 signaling pathway

Definition

TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF3 -> (CREBBP,EP300) => IFNB1

Expanded

7098 -> 148022 -> 7187 -> (9641+29110) -> 3661 -> (1387,2033) => 3456

Class

nt06517 TLR signaling
nt06263 Hepatocellular carcinoma
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166 Human papillomavirus (HPV)

Type

Reference

Pathway

hsa04620

Toll-like receptor signaling pathway

Gene

7098	TLR3; toll like receptor 3

148022

TICAM1; toll like receptor adaptor molecule 1

7187	TRAF3; TNF receptor associated factor 3

9641	IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon

29110

TBK1; TANK binding kinase 1

3661	IRF3; interferon regulatory factor 3

1387	CREBBP; CREB binding protein

2033	EP300; E1A binding protein p300

3456	IFNB1; interferon beta 1

Reference

PMID:17395581

Authors

Uematsu S, Akira S.

Title

Toll-like receptors and Type I interferons.

Journal

J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200

Reference

PMID:16497588

Authors

Akira S, Uematsu S, Takeuchi O.

Title

Pathogen recognition and innate immunity.

Journal

Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015

Reference

PMID:20561711

Authors

Gauzzi MC, Del Corno M, Gessani S

Title

Dissecting TLR3 signalling in dendritic cells.

Journal

Immunobiology 215:713-23 (2010)
DOI:10.1016/j.imbio.2010.05.008

Reference

PMID:20046508

Authors

Boo KH, Yang JS

Title

Intrinsic cellular defenses against virus infection by antiviral type I interferon.

Journal

Yonsei Med J 51:9-17 (2010)
DOI:10.3349/ymj.2010.51.1.9

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Gene (9)   
   KEGG GENES (9)   
Literature (4)   
   PubMed (4)   
All databases (14)   

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