KEGG NETWORK: N00030

NETWORK: N00030

Entry

N00030                      Network

Name

EGF-EGFR-RAS-PI3K signaling pathway

Definition

EGF -> EGFR -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD

Expanded

1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572

Class

nt06260 Colorectal cancer
nt06268 Melanoma
nt06214 PI3K signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)

Type

Reference

Pathway

hsa04151

PI3K-Akt signaling pathway

Gene

1950	EGF; epidermal growth factor

1956	EGFR; epidermal growth factor receptor

2885	GRB2; growth factor receptor bound protein 2

6654	SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1

6655	SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2

3265	HRAS; HRas proto-oncogene, GTPase

3845	KRAS; KRAS proto-oncogene, GTPase

4893	NRAS; NRAS proto-oncogene, GTPase

5290	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

5291	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

5293	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

207	AKT1; AKT serine/threonine kinase 1

208	AKT2; AKT serine/threonine kinase 2

10000

AKT3; AKT serine/threonine kinase 3

572	BAD; BCL2 associated agonist of cell death

Metabolite

C05981

Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:12040186

Authors

Cantley LC

Title

The phosphoinositide 3-kinase pathway.

Journal

Science 296:1655-7 (2002)
DOI:10.1126/science.296.5573.1655

Reference

PMID:26071484

Authors

Bertotti A, Sassi F

Title

Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies.

Journal

Clin Cancer Res 21:3377-83 (2015)
DOI:10.1158/1078-0432.CCR-14-0848

Reference

PMID:25312969

Authors

Makker A, Goel MM, Mahdi AA

Title

PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update.

Journal

J Mol Endocrinol 53:R103-18 (2014)
DOI:10.1530/JME-14-0220

Reference

PMID:9838078

Authors

Wymann MP, Pirola L

Title

Structure and function of phosphoinositide 3-kinases.

Journal

Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (15)   
   KEGG GENES (15)   
Literature (4)   
   PubMed (4)   
All databases (21)   

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