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A web tool for measuring gene semantic similarities by combining gene ontology and gene co-function networks

Published: 09 September 2015 Publication History

Abstract

Gene Ontology(GO) is one of the most popular bioinformatic resource to study functional relationships between genes. However, the existing tools for calculating the semantic similarity are limited since they only rely on GO annotations and structure. We provide a working demonstration of a web tool that calculates functional similarities between GO terms by integrating gene co-function networks and information from GO. We demonstrate the function of the web tool by comparing remote GO terms.

References

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  1. A web tool for measuring gene semantic similarities by combining gene ontology and gene co-function networks

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    cover image ACM Conferences
    BCB '15: Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics
    September 2015
    683 pages
    ISBN:9781450338530
    DOI:10.1145/2808719
    Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the Owner/Author.

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    Publication History

    Published: 09 September 2015

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    Author Tags

    1. gene ontology
    2. semantic similarity
    3. software tools

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