Radio frequency over fiber (RoF) advanced technology is already integrated into current 3G and 4G radio access networks in which the digital unit and remote radio head equipped with nonlinear high power amplifiers (HPAs) are connected through the RoF-based fronthaul links. In this study, we investigated the degradation in the adjacent channel leakage ratio (ACLR) of equipment with the adaptive linearizer RF HPA when both the direct and feedback paths of the transmitting system include RoF links. We show that an ACLR exceeding -57dBc @ 5-MHz offset, which completely satisfies the requirements of the 3GPP technical specifications, can be achieved for a 20-W-class Doherty power amplifier linearized through commercial RoF links. Experiments showed that the achieved ACLR strongly depends on the RoF-link noise figure and that most of the nonlinear distortions caused by RoF can be completely suppressed with the proposed joint linearization approach for simultaneous linearization of RoF and HPA nonlinearities with a single common “joint” linearizer. Experimental results confirm significant ACLR performance enhancements as a result of RoF noise floor reduction, which is achieved under RoF driving conditions optimized together with joint RoF and HPA linearization. Our joint linearization approach via RoF links is confirmed to be applicable for next-generation mobile fronthaul architectures.