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Standard Mode for job manager, batch processing, Phyre alarm and other advanced options Retrieve Phyre Job Id  
 
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  Protein Homology/analogY Recognition Engine V 2.2
 

gives you access to our Expert Mode features.Info icon

We are pleased to announce the release of Phyre2.2, which contains a number of new features (see the help menu for more details).

If you really need to use the old version, checking the "Traditional Phyre2" button will allow this.

One-to-One ThreadingInfo icon (which models your sequence against a user-supplied model) can now use models directly from the AlphaFold Protein Structure DatabaseInfo icon.

Please do not use "intensive mode" unless your search using "normal mode" indicates that a single model does not cover most of your sequence. Info icon

Current Phyre2 server load = 0% (normal running) Info icon

E-mail address:
Optional Job description
or upload contents of sequence file Info icon
or UniProt accession Info icon
Modelling Mode info icon
Please tick as appropriate. info icon || | |
 

Examples of running Phyre2.2 on UniProt accession P0DV45 in Normal, Intensive and AlphaThread modes Info icon

5960710 submissions since Feb 14 2011

Other Resources
Missense3D Portal: a suite of resources for the analysis of amino acid substitutions in proteins
GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
 
© Structural Bioinformatics Group,
Imperial College,
London
Michael Sternberg

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