Abstract
A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenoma / genetics
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Adenoma / pathology
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Carcinoma / genetics
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Carcinoma / pathology
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Codon
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Colonic Neoplasms / genetics*
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Colonic Neoplasms / pathology
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DNA / genetics
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Humans
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Mutation*
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Nucleic Acid Hybridization
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Oncogenes*
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Rectal Neoplasms / genetics*
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Rectal Neoplasms / pathology