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Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein

Int J Antimicrob Agents. 2020 Aug;56(2):105998. doi: 10.1016/j.ijantimicag.2020.105998. Epub 2020 Apr 28.

Abstract

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mechanism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2.

Keywords: Antiviral; COVID-19; Coronavirus; Molecular dynamics; Spike glycoprotein.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Betacoronavirus / drug effects*
  • Betacoronavirus / isolation & purification
  • Biopolymers / chemistry*
  • COVID-19
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / virology
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Pandemics
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / virology
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / antagonists & inhibitors*

Substances

  • Antiviral Agents
  • Biopolymers
  • Indoles
  • Spike Glycoprotein, Coronavirus
  • umifenovir