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Establishing a heart transplant programme using donation after circulatory-determined death donors: a United Kingdom based single-centre experience

Interact Cardiovasc Thorac Surg. 2019 Sep 1;29(3):422-429. doi: 10.1093/icvts/ivz121.

Abstract

Objectives: Demand for heart transplant donors worldwide continues to outstrip supply. Transplanting hearts following donation after circulatory-determined death (DCD) is increasingly recognized as a safe and effective alternative. As the fourth centre worldwide to have established such a programme, our goal was to present our initial experience.

Methods: This was a single-centre retrospective observational study. All DCD hearts were retrieved using direct procurement and perfusion. Continuous normothermic perfusion of the procured heart was then established on the TransMedics® Organ Care System. The primary outcome of this study was the 30-day survival rate.

Results: Between May 2017 and December 2018, 8 DCD hearts were procured and 7 were subsequently implanted, including in 2 patients who had left ventricular assist devices explanted. During the same time period, 30 patients received donation after brainstem death heart transplants. Therefore, the DCD heart transplant programme led to a 23% increase in transplant activity. The median donation warm ischaemic time was 34 min [interquartile range (IQR) 31-39 min]. The median functional warm ischaemic time was 28 min (IQR 25-30 min). The median time spent by the organ on the Organ Care System was 263 min (IQR 242-296 min). The overall 30-day survival rate was 100% and the 90-day survival rate was 86%. Postoperative extracorporeal membrane oxygenation was required in 3/7 (43%).

Conclusions: DCD heart transplants can lead to a 23% increase in heart transplant activity and should be adopted by more institutions across the world. Already established transplant programmes with good early outcomes can start such a programme safely.

Keywords: Donation after circulatory-determined death (DCD); Heart transplantation; Organ Care System (OCS); TransMedics®.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Heart Transplantation / mortality*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Survival Rate / trends
  • Tissue Donors*
  • Tissue and Organ Procurement / organization & administration*
  • United Kingdom / epidemiology
  • Warm Ischemia / methods*
  • Young Adult