The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression

Arch Immunol Ther Exp (Warsz). 2018 Jun;66(3):183-197. doi: 10.1007/s00005-017-0494-2. Epub 2017 Dec 5.

Authors

Chon-Kit Chou^{1

2}, Ya-Ting Yang², Ho-Chun Yang², Shih-Shin Liang^{2

3}, Tsu-Nai Wang^{3

4}, Po-Lin Kuo⁵, Hui-Min David Wang⁶, Eing-Mei Tsai^{7

8

9}, Chien-Chih Chiu^{10

11

12

13

14}

Affiliations

¹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
² Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
³ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁴ Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁵ Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.
⁶ Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, 402, Taiwan.
⁷ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
⁸ Headquarters of Research Centers, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
⁹ Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan. tsaieing@kmu.edu.tw.
¹⁰ Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹¹ Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹² Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 804, Taiwan. cchiu@kmu.edu.tw.
¹³ Department of Medical Research, Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.
¹⁴ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. cchiu@kmu.edu.tw.

PMID: 29209738
DOI: 10.1007/s00005-017-0494-2

Abstract

Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner. In this review, we comprehensively summarize the accumulated literature regarding the multifaceted roles of DEHP in the activation of the nuclear receptors, the alteration of the redox homeostasis, epigenetic modifications and the acquisition of chemoresistance.

Keywords: Chemoresistance; DEHP; Epigenetic modifications; Nuclear receptors; Redox homeostasis; Tumorigenesis.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use*
Carcinogenesis
Diethylhexyl Phthalate / chemistry
Diethylhexyl Phthalate / therapeutic use*
Drug Resistance, Neoplasm
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic / drug effects
Homeostasis
Humans
Neoplasms / metabolism*
Oxidation-Reduction
Phthalic Acids
Plasticizers / chemistry
Plasticizers / therapeutic use*
Polyvinyl Chloride
Receptors, Cytoplasmic and Nuclear / metabolism

Substances

Antineoplastic Agents
Phthalic Acids
Plasticizers
Receptors, Cytoplasmic and Nuclear
phthalic acid
Polyvinyl Chloride
Diethylhexyl Phthalate

Abstract

Publication types

MeSH terms

Substances

Grants and funding