Mathematical model for studying genetic variation in terms of restriction endonucleases

Proc Natl Acad Sci U S A. 1979 Oct;76(10):5269-73. doi: 10.1073/pnas.76.10.5269.

Authors

PMID: 291943
PMCID: PMC413122
DOI: 10.1073/pnas.76.10.5269

Abstract

A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Base Sequence
Computers
DNA Restriction Enzymes*
DNA, Mitochondrial*
Genetic Variation*
Mathematics
Models, Biological

Substances

DNA, Mitochondrial
DNA Restriction Enzymes