TLRgeting Evasion of Immune Pathways in Glioblastoma

Cell Stem Cell. 2017 Apr 6;20(4):422-424. doi: 10.1016/j.stem.2017.03.018.

Author

Affiliation

¹ Unit of Molecular Neuro-Oncology, Foundation IRCCS Neurological Institute Carlo Besta, 20133 Milan, Italy. Electronic address: gaetano.finocchiaro@istituto-besta.it.

PMID: 28388423
DOI: 10.1016/j.stem.2017.03.018

Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.

Publication types

Comment

MeSH terms

Brain Neoplasms
Glioblastoma / immunology*
Humans
Neoplastic Stem Cells*
Signal Transduction