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On the masked mycotoxin zearalenone-14-glucoside. Does the mask truly hide?

Toxicon. 2016 Mar 1:111:139-42. doi: 10.1016/j.toxicon.2016.01.053. Epub 2016 Jan 12.

Abstract

In the matter of foodborne mycotoxins, beside a number of regulated compounds, regulations are totally missing for phase-II plant metabolites--the toxicological knowledge of which is still in its infancy. Currently, zearalenone-14-glucoside is in the pipeline and its toxicological role is under a glowing scientific debate. In our work it clearly showed high toxicological concerns as it is prone to conversion to well-known toxic compounds (i.e. zearalenone and both zearalenol isomers) when exposed to breast cancer cells culture. The need of future risk assessment studies has been pointed out accordingly.

Keywords: Bioconversion; Human cell lines; Hydrolysis; Masked mycotoxins; Zearalenone.

MeSH terms

  • Humans
  • MCF-7 Cells
  • Zearalenone / chemistry
  • Zearalenone / metabolism*

Substances

  • Zearalenone