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Transdermal drug delivery: 30+ years of war and still fighting!

J Control Release. 2014 Sep 28:190:150-6. doi: 10.1016/j.jconrel.2014.05.022. Epub 2014 May 19.

Abstract

By any measure, transdermal drug delivery (TDD) is a successful controlled release technology. Over the last 30+ years, a steady flux of transdermal products have received regulatory approval and reached the market. For the right compounds, TDD is an effective and preferred route of administration; for others, delivery across the skin makes no sense at all. Currently, the "rules" that govern (passive) TDD feasibility are clearly understood, and research activity is focused on novel approaches that strive to subvert skin's excellent barrier function, and broaden the range of active species amenable to percutaneous administration.

Keywords: Controlled release; Skin barrier function; Transdermal drug delivery.

Publication types

  • Historical Article

MeSH terms

  • Administration, Cutaneous*
  • Delayed-Action Preparations / administration & dosage*
  • Delayed-Action Preparations / economics
  • Delayed-Action Preparations / history
  • Delayed-Action Preparations / pharmacokinetics
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Skin Absorption

Substances

  • Delayed-Action Preparations