Ischemic preconditioning for cell-based therapy and tissue engineering

Pharmacol Ther. 2014 May;142(2):141-53. doi: 10.1016/j.pharmthera.2013.12.002. Epub 2013 Dec 7.

Authors

Sarah T Hsiao¹, Rodney J Dilley², Gregory J Dusting³, Shiang Y Lim⁴

Affiliations

¹ Department of Cardiovascular Science, University of Sheffield, United Kingdom.
² Ear Science Institute Australia and Ear Sciences Centre, School of Surgery, University of Western Australia, Nedlands, Western Australia, Australia.
³ Centre for Eye Research Australia and Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia; Department of Ophthalmology, University of Melbourne, East Melbourne, Victoria, Australia; Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia; O'Brien Institute, Fitzroy, Victoria, Australia.
⁴ Department of Surgery, University of Melbourne, Fitzroy, Victoria, Australia; O'Brien Institute, Fitzroy, Victoria, Australia. Electronic address: maxlim@unimelb.edu.au.

PMID: 24321597
DOI: 10.1016/j.pharmthera.2013.12.002

Abstract

Cell- and tissue-based therapies are innovative strategies to repair and regenerate injured hearts. Despite major advances achieved in optimizing these strategies in terms of cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. The non-genetic approach of ischemic/hypoxic preconditioning to enhance cell- and tissue-based therapies has received much attention in recent years due to its non-invasive drug-free application. Here we discuss the current development of hypoxic/ischemic preconditioning to enhance stem cell-based cardiac repair and regeneration.

Keywords: Cell therapy; Hypoxic preconditioning; Ischemic preconditioning; Paracrine; Stem cell; Tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Combined Modality Therapy
Humans
Ischemic Preconditioning, Myocardial*
Myocardial Reperfusion Injury / pathology
Myocardial Reperfusion Injury / physiopathology
Myocardial Reperfusion Injury / therapy*
Regeneration
Regenerative Medicine / methods*
Stem Cell Transplantation*
Tissue Engineering*
Treatment Outcome