Abstract
Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as a major player in the 3′–5′ exonucleolytic decay of transcripts. Furthermore, they demonstrate a strong connection between terminal uridylation of the RNA substrate and enzymatic activity.
MeSH terms
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Animals
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Cytoplasm / metabolism*
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Exonucleases / metabolism*
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Exoribonucleases / metabolism*
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Exosomes / genetics*
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Exosomes / metabolism*
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Fetal Macrosomia / enzymology*
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Fetal Macrosomia / genetics*
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Humans
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MicroRNAs / metabolism*
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RNA Processing, Post-Transcriptional*
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RNA Stability / genetics*
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / metabolism*
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Ribonucleases / metabolism*
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Schizosaccharomyces / genetics*
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Wilms Tumor / enzymology*
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Wilms Tumor / genetics*
Substances
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MicroRNAs
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RNA, Messenger
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RNA-Binding Proteins
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DIS3L2 protein, human
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Exonucleases
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Exoribonucleases
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Ribonucleases