Abstract
Engineered polyethylene glycol-maleimide matrices for regenerative medicine exhibit improved reaction efficiency and wider range of Young’s moduli by utilizing maleimide cross-linking chemistry. This hydrogel chemistry is advantageous for cell delivery due to the mild reaction that occurs rapidly enough for in situ delivery, while easily lending itself to “plug-and-play” design variations such as incorporation of enzyme-cleavable cross-links and cell-adhesion peptides.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Line
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Collagen / metabolism
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Cross-Linking Reagents / chemistry*
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Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
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Kinetics
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Maleimides / chemistry*
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Mice
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Oligopeptides / chemistry
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Oligopeptides / metabolism
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Polyethylene Glycols / chemistry*
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Regenerative Medicine
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Transfection
Substances
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Cross-Linking Reagents
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Maleimides
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Oligopeptides
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maleimide
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Polyethylene Glycols
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arginyl-glycyl-aspartic acid
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Collagen