[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Cancer-selective apoptotic effects of extracellular and intracellular Par-4

Oncogene. 2010 Jul 8;29(27):3873-80. doi: 10.1038/onc.2010.141. Epub 2010 May 3.

Abstract

Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / chemistry
  • Apoptosis Regulatory Proteins / metabolism*
  • Apoptosis*
  • Endoplasmic Reticulum Chaperone BiP
  • Extracellular Space / metabolism*
  • Humans
  • Intracellular Space / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Tumor Suppressor Proteins / chemistry
  • Tumor Suppressor Proteins / metabolism

Substances

  • Apoptosis Regulatory Proteins
  • Endoplasmic Reticulum Chaperone BiP
  • HSPA5 protein, human
  • Tumor Suppressor Proteins
  • prostate apoptosis response-4 protein