Abstract
Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Basic-Leucine Zipper Transcription Factors / physiology
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Cell Transformation, Viral
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DNA Damage
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Gene Products, rex / physiology
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Gene Products, tax / physiology
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Genomic Instability
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / physiology*
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Humans
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Leukemia-Lymphoma, Adult T-Cell / virology
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Retroviridae Proteins
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T-Lymphocytes / pathology*
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Viral Proteins / physiology
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Virus Replication
Substances
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Basic-Leucine Zipper Transcription Factors
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Gene Products, rex
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Gene Products, tax
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HBZ protein, human T-cell leukemia virus type I
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Retroviridae Proteins
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Viral Proteins
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rex Protein, Human T-lymphotropic virus 1
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tax protein, Human T-lymphotrophic virus 1