Abstract
It is now well accepted that the innate immune system recognizes both damage (or danger)- and pathogen-associated molecular patterns (DAMP and PAMP, respectively) through pattern recognition receptors, such as Toll-like receptors (TLR) and/or Nod-like receptors (NLR). Less clear are whether and how the response to PAMP and DAMP are regulated differentially. The answers may reveal whether the primary goal of the immune system is to defend against infections or to alert the host of tissue injuries. We demonstrated recently that the host response to DAMP is controlled by a DAMP-CD24-Siglec axis. Here we propose a key role for the CD24-Siglec pathway in discriminating between DAMPs and PAMPs.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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CD24 Antigen / immunology
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CD24 Antigen / metabolism*
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Heat-Shock Proteins / immunology
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Humans
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Immunity, Innate
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Lectins / immunology
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Lectins / metabolism*
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Lymphocyte Activation
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Mice
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Nod1 Signaling Adaptor Protein / immunology
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Protein Binding
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Protein Tyrosine Phosphatase, Non-Receptor Type 6 / immunology
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Protein Tyrosine Phosphatase, Non-Receptor Type 6 / metabolism
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Receptors, Pattern Recognition / immunology
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Sialic Acid Binding Immunoglobulin-like Lectins
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Toll-Like Receptor 2 / immunology
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Toll-Like Receptor 4 / immunology
Substances
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CD24 Antigen
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Heat-Shock Proteins
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Lectins
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Nod1 Signaling Adaptor Protein
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Receptors, Pattern Recognition
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Sialic Acid Binding Immunoglobulin-like Lectins
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Toll-Like Receptor 2
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Toll-Like Receptor 4
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Protein Tyrosine Phosphatase, Non-Receptor Type 6