Abstract
The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cryptococcus neoformans / chemistry
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Cryptococcus neoformans / enzymology*
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Cryptococcus neoformans / genetics
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Cryptococcus neoformans / metabolism*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Glycosphingolipids / chemistry
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Glycosphingolipids / metabolism*
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Pentosyltransferases / genetics
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Pentosyltransferases / metabolism*
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Xylose / metabolism*
Substances
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Fungal Proteins
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Glycosphingolipids
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Xylose
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Pentosyltransferases
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beta 1,2-xylosyltransferase