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Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes

Biochem Biophys Res Commun. 2008 Feb 1;366(1):219-25. doi: 10.1016/j.bbrc.2007.11.119. Epub 2007 Dec 3.

Abstract

Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-alpha and PPARgamma. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARgamma antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARgamma activations. The results indicate that auraptene activates PPARgamma in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects
  • Adipocytes / metabolism*
  • Animals
  • Chemokine CCL2 / metabolism*
  • Citrus / metabolism*
  • Coumarins / administration & dosage*
  • Dose-Response Relationship, Drug
  • Mice
  • Peroxisome Proliferator-Activated Receptors / agonists*
  • Plant Extracts / administration & dosage*

Substances

  • Chemokine CCL2
  • Coumarins
  • Peroxisome Proliferator-Activated Receptors
  • Plant Extracts
  • aurapten