Abstract
A new in vitro system based on real-time PCR was developed for evaluation of human herpesvirus 8 susceptibility to antiviral agents. Cidofovir had the greatest inhibitory activity against HHV-8 (50% inhibitory concentration [IC(50)], 0.43 microM) followed by ganciclovir (2.61 microM), adefovir (18.00 microM), acyclovir (31.00 microM), and foscarnet (34.15 microM). The potential therapeutic efficacy for HHV-8 (i.e., peak serum drug level/IC(50)) is highest for cidofovir (167) and foscarnet (22).
MeSH terms
-
Antiviral Agents / blood
-
Antiviral Agents / pharmacology*
-
Cidofovir
-
Cytosine / analogs & derivatives*
-
Cytosine / blood
-
Cytosine / pharmacology*
-
Ganciclovir / blood
-
Ganciclovir / pharmacology
-
Herpesvirus 8, Human / drug effects*
-
Herpesvirus 8, Human / genetics
-
Humans
-
Microbial Sensitivity Tests
-
Organophosphonates*
-
Organophosphorus Compounds / blood
-
Organophosphorus Compounds / pharmacology*
-
Polymerase Chain Reaction / methods
-
Regression Analysis
Substances
-
Antiviral Agents
-
Organophosphonates
-
Organophosphorus Compounds
-
Cytosine
-
Cidofovir
-
Ganciclovir