Abstract
Development of an orally-administered systemic agent that could reduce the effects of u.v. exposure on skin could potentially have a major effect on the incidence of skin cancers and photo-ageing. A number of micronutrients have been suggested to have metabolic properties that could induce this protection, and our data indicate that n-3 polyunsaturated fatty acids are particularly effective in this role. The mechanisms of action of n-3 polyunsaturated fatty acids appear to depend on their anti-inflammatory properties, acting to reduce the u.v.-induced release of cytokines and other mediators from a variety of skin cell types.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / radiation effects
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use
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Antioxidants / administration & dosage
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Antioxidants / therapeutic use*
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Dietary Supplements
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Fatty Acids, Omega-3 / administration & dosage
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Fatty Acids, Omega-3 / therapeutic use*
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Humans
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Micronutrients / administration & dosage*
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Micronutrients / therapeutic use
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Skin / drug effects*
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Skin / radiation effects
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Skin Neoplasms / drug therapy
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Skin Neoplasms / immunology
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Skin Neoplasms / prevention & control*
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Ultraviolet Rays / adverse effects*
Substances
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Antineoplastic Agents
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Antioxidants
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Fatty Acids, Omega-3
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Micronutrients