Abstract
We report the case of a patient with recurrent squamous cell carcinoma of the cervix, that metastasized to the paraaortic and supraclavicular lymph nodes and the lungs after primary radiotherapy for stage IIB. The tumor was refractory to multiple drug regimens. A combination of paclitaxel (135 mg/m2 intravenous infusion over 24) hours and carboplatin with a target area under the curve of 7.5 mg-min/mL were then administered and repeated every 4 weeks. The patient tolerated the chemotherapy well with myeloprotection from granulocyte colony-stimulating factor and the disease went into remission. Thus, the combination of paclitaxel and carboplatin may have antitumor activity in advanced or recurrent squamous cell carcinoma of the cervix.
MeSH terms
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Adult
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carboplatin / administration & dosage
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / secondary
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Chemotherapy, Adjuvant
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Disease-Free Survival
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Female
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Humans
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Lung Neoplasms / drug therapy
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Lung Neoplasms / secondary*
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Lymphatic Metastasis
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Neoplasm Recurrence, Local / diagnosis
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Neoplasm Recurrence, Local / drug therapy*
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Neoplasm Recurrence, Local / therapy
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Paclitaxel / administration & dosage
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Uterine Cervical Neoplasms / diagnosis
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Uterine Cervical Neoplasms / drug therapy*
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Uterine Cervical Neoplasms / therapy
Substances
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Carboplatin
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Paclitaxel