Abstract
Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Cell Membrane / metabolism
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Humans
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Mink
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Molecular Sequence Data
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Phosphorus Radioisotopes
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Phosphorylation
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Protein Serine-Threonine Kinases*
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Receptor Protein-Tyrosine Kinases / metabolism*
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Receptor, Transforming Growth Factor-beta Type I
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Receptor, Transforming Growth Factor-beta Type II
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Receptors, Transforming Growth Factor beta / metabolism*
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Signal Transduction
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Transfection
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Transforming Growth Factor beta / metabolism*
Substances
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Phosphorus Radioisotopes
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Receptors, Transforming Growth Factor beta
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Transforming Growth Factor beta
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Receptor Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases
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Receptor, Transforming Growth Factor-beta Type I
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Receptor, Transforming Growth Factor-beta Type II