Abstract
Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth. The extent to which the negative regulators are decreased during this switch may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
MeSH terms
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Angiostatins
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Animals
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Arthritis, Rheumatoid / physiopathology
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Endothelial Growth Factors / physiology
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Eye / blood supply
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Humans
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Lymphokines / physiology
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Mice
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Neoplasm Metastasis*
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Neoplasms / blood supply
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Neovascularization, Pathologic*
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Peptide Fragments / therapeutic use
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Plasminogen / therapeutic use
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Psoriasis / physiopathology
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Time Factors
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
Substances
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Endothelial Growth Factors
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Lymphokines
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Peptide Fragments
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
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Angiostatins
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Plasminogen