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Homo sapiens Gene: TYMP
Summary
InnateDB Gene IDBG-13815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYMP
Gene Name thymidine phosphorylase
Synonyms ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP
Species Homo sapiens
Ensembl Gene ENSG00000025708
Encoded Proteins
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
thymidine phosphorylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50525752-50530085
Strand Reverse strand
Band q13.33
Transcripts
ENST00000252029 ENSP00000252029
ENST00000395681 ENSP00000379038
ENST00000395680 ENSP00000379037
ENST00000395678 ENSP00000379036
ENST00000425169 ENSP00000395875
ENST00000487577
ENST00000476284
ENST00000487162
ENST00000613148 ENSP00000477950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004645 phosphorylase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0008083 growth factor activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016763 transferase activity, transferring pentosyl groups
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0001525 angiogenesis
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006260 DNA replication
GO:0006935 chemotaxis
GO:0008152 metabolic process
GO:0030154 cell differentiation
GO:0043097 pyrimidine nucleoside salvage
GO:0044281 small molecule metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Pyrimidine salvage reactions pathway
Pyrimidine catabolism pathway
Metabolism of nucleotides pathway
Pyrimidine metabolism pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
Bladder cancer pathway
Drug metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.180903 Hs.685254
RefSeq NM_001113755 NM_001113756 NM_001257988 NM_001257989 NM_001953
HUGO
OMIM
CCDS CCDS14096 CCDS58811
HPRD 08833
IMGT
EMBL
GenPept
RNA Seq Atlas