Overview
The Molecular Signatures Database (MSigDB) is a resource of tens of thousands of annotated gene sets for use with GSEA software,
divided into Human and Mouse collections.
From this web site, you can
- Examine a gene set and its annotations. See, for example, the
HALLMARK_APOPTOSIS human gene set page.
- Browse gene sets by name or collection.
- Search for gene sets by keyword.
- Investigate gene sets:
- Compute overlaps between your gene set and gene sets in MSigDB.
- Categorize members of a gene set by gene families.
- View the expression profile of a gene set in a provided public expression compendia.
- Investigate the gene set in the online biological network repository NDEx
- Download gene sets.
License Terms
GSEA and MSigDB are available for use under these license terms.
Please register to download the GSEA software and the MSigDB gene sets,
and to use our web tools. After registering, you can log in at any time using your email address. Registration is free.
Its only purpose is to help us track usage for reports to our funding agencies.
Current Version
Human MSigDB v2024.1.Hs updated August 2024.
Release notes.
Mouse MSigDB v2024.1.Mm updated August 2024.
Release notes.
Citing the MSigDB
To cite your use of the Molecular Signatures Database (MSigDB), a joint project of UC San Diego and Broad Institute,
please reference Subramanian, Tamayo, et al.
(2005, PNAS) and
one or more of the following as appropriate:
Liberzon, et al. (2011, Bioinformatics),
Liberzon, et al. (2015, Cell Systems),
and also the source for the gene set as listed on the gene set page. If you use Mouse MSigDB, please also cite
Castanza, et al. (2023, Nature Methods).
Funding
GSEA and MSigDB are currently funded by a grant from NCI's
Informatics Technology for Cancer Research (ITCR)
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