Abstract The main effectors of apoptosis encompass proteases from the caspase family, …
caspases constitute a minimal two-step signaling pathway. The apical (initiator) caspases are …

… , the initiator caspases then cleave and activate the executioner caspases-3 and -7. Unregulated
caspase activity would be lethal for a cell, so to prevent this the cell stores caspases as …

… caspase and at this time a total of 12 caspases have been identified in human. Caspases …
Once activated by cleavage after specific aspartic acids, caspases cleave a host of cellular …

… human and murine caspases. The catalytic parts of the inflammatory caspases cluster
separately from the apoptotic caspases. In the cluster of the inflammatory caspases, two separate …

… Indeed, the list of proteins that are reported to be cleaved by caspases in vitro … caspase
substrate recognition and specificity, give resources for the discovery and annotation of caspase …

… Caspases involved in apoptosis have been subclassified by … caspases (caspase-8 and
-9) or executioner caspases (… caspase can cleave and activate other executioner caspases, …

… during the apoptosis in caspase-3-/- cells, from which we can see that caspase-3 is not the
only apoptosis executioner caspase [3]. Because all substrates of caspase-3 contain DEVD …

… caspase substrates are specifically cleaved by caspase-3 or a related protease, and caspase-3
can process pro-caspases 2… 9, further illustrating the extensive involvement of caspase-3 …

… The finding that the IAPs can also bind pro-Caspase 941 may provide the answer to this …
downstream caspases, including Caspase 3. To date the association of IAPs with pro-caspases …

… the contribution of caspases and caspase-independent … and caspase activation: cell death
through caspase activation, cell death with caspase activation, and cell death without caspase …