User profiles for "author:L Baggio"
 | Laurie L. BaggioLunenfeld Tanenbaum Research Institute Verified email at lunenfeld.ca Cited by 15743 |
Biology of incretins: GLP-1 and GIP
LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier
This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …
[HTML][HTML] Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease
LL Baggio, DJ Drucker - Molecular metabolism, 2021 - Elsevier
Background Glucagon-like peptide-1 receptor (GLP-1R) agonists are approved for the
treatment of type 2 diabetes and obesity and elicit robust improvements in glycemic control …
treatment of type 2 diabetes and obesity and elicit robust improvements in glycemic control …
Therapeutic approaches to preserve islet mass in type 2 diabetes
LL Baggio, DJ Drucker - Annu. Rev. Med., 2006 - annualreviews.org
Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the
setting of inadequate β-cell compensation. Currently available therapeutic agents lower …
setting of inadequate β-cell compensation. Currently available therapeutic agents lower …
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
H Ellingsgaard, I Hauselmann, B Schuler, AM Habib… - Nature medicine, 2011 - nature.com
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of
interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin …
interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin …
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
MH Noyan-Ashraf, MA Momen, K Ban, AM Sadi… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2
diabetes, and transient GLP-1 administration improved cardiac function in humans after …
diabetes, and transient GLP-1 administration improved cardiac function in humans after …
GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
Perturbation of endoplasmic reticulum (ER) homeostasis impairs insulin biosynthesis, β cell
survival, and glucose homeostasis. We show that a murine model of diabetes is associated …
survival, and glucose homeostasis. We show that a murine model of diabetes is associated …
A recombinant human glucagon-like peptide (GLP)-1–albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor–dependent pathways coupled with …
Peptide hormones exert unique actions via specific G protein–coupled receptors; however,
the therapeutic potential of regulatory peptides is frequently compromised by rapid …
the therapeutic potential of regulatory peptides is frequently compromised by rapid …
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC
3.4. 14.5), specifically cleave off N-terminal dipeptides from substrates having proline or …
3.4. 14.5), specifically cleave off N-terminal dipeptides from substrates having proline or …
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
Background & Aims: Gut-derived peptides including ghrelin, cholecystokinin (CCK), peptide
YY (PYY), glucagon-like peptide (GLP-1), and GLP-2 exert overlapping actions on energy …
YY (PYY), glucagon-like peptide (GLP-1), and GLP-2 exert overlapping actions on energy …
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
…, ME Lopez, AN Hollenberg, L Baggio… - The Journal of …, 2002 - Am Soc Clin Investig
Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that
stimulates insulin secretion. GLP-1 is also a brain neuropeptide that controls feeding and …
stimulates insulin secretion. GLP-1 is also a brain neuropeptide that controls feeding and …