Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease
worldwide. The diagnostic histologic hallmark is dominant or codominant IgA staining on …

Progressive kidney failure is a genetically and clinically heterogeneous group of disorders.
Podocyte foot processes and the interposed glomerular slit diaphragm are essential …

The main manifestations of nephrotic syndrome include proteinuria, hypoalbuminemia,
edema, hyperlipidemia and lipiduria. Common causes of nephrotic syndrome are diabetic …

Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in
normal and remnant kidney rats. Background Hyperuricemia has been associated with renal …

Background B-cell anomalies play a role in the pathogenesis of membranous nephropathy.
B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine …

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination …

Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn,
the metabolic syndrome has been epidemiologically linked with renal progression. The …

Mildly hyperuricemic rats develop renin-dependent hypertension and interstitial renal
disease. Hyperuricemia might also induce changes in glomerular hemodynamics …

Endothelial dysfunction is a characteristic feature during the renal damage induced by mild
hyperuricemia. The mechanism by which uric acid reduces the bioavailability of intrarenal …

The molecular link between proteinuria and hyperlipidemia in nephrotic syndrome is not
known. We show in the present study that plasma angiopoietin-like 4 (Angptl4) links …