The etiology and pathogenesis of psoriasis – one of the most common chronic, inflammatory,
hyperproliferative skin disorders of man – have long fascinated dermatologists, …

Etiopatogeneza łuszczycy, choroby zdefiniowanej i wyróżnionej jako odrębna jednostka
dermatologiczna przez brytyjskiego lekarza Roberta Willana już prawie 200 lat temu, pozostaje …

The development and maintenance of psoriatic inflammation are due to concern with the
skin’s innate and adaptive immune responses. The innate immune system is activated by …

By virtue of the dynamic nature of the scientific process, the description of the pathogenesis
of a disease is always a work in progress. Each day new research shapes and refines our …

▪ Abstract Psoriasis is an inflammatory/autoimmune disease and, as with many autoimmune
diseases, is associated with alleles from the major histocompatibility complex (MHC). With …

The skin is the only organ capable of making vitamin D when it is exposed to sunlight. Both
the keratinocytes and fibroblasts have a vitamin D receptor (VDR), and thus respond to the …

The etiopathogenesis of psoriasis has not been fully elucidated. Nowadays, psoriasis is
perceived as a multifactorial disease of genetic origin, in which complex immunological …

The current understanding of the function of natural killer (NK) T cells in innate immunity and
their potential to control acquired specific immunity, as well as the remarkable efficacy of …

In a CD18 hypomorphic polygenic PL/J mouse model, the severe reduction of CD18 (β 2
integrin) to 2–16% of wild-type levels leads to the development of a psoriasiform skin disease. …

Psoriasis is a chronic inflammatory skin disorder characterized by hyper-proliferation of basal
keratinocytes, thickened and scaly epidermis, and recruitment of inflammatory cells to the …