Rfam: The RNA families database

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Rfam 15.0 (September 2024, 4178 families)

The Rfam database is a collection of RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models

Learn more about Rfam →

Search and browse Rfam

Getting started

Sequence search

Annotate your sequences with RNA families and visualise their secondary structure using R2DT

Search by sequence

Downloads

Download covariance models, FASTA sequences, database dumps, previous releases, and more

Open FTP Archive

Help

Access Rfam using the API and public MySQL database, or learn how to annotate genomes using Infernal

Rfam Help

Tweets

Announcements

Citing Rfam

If you use Rfam, please cite our latest papers:

Rfam 15: RNA families database in 2025
Ontiveros-Palacios et al., Nucleic Acids Research (2024)

Non-coding RNA analysis using the Rfam database.
Kalvari et al., Current Protocols in Bioinformatics (2018)

View all Rfam papers

Current projects

3D Families

Explore families with 3D Information →

Viruses

Discover new Coronaviridae and Flaviviridae RNA families →

microRNAs

Find out about the first phase of synchronising microRNA families between miRBase and Rfam →

Featured families

SAM riboswitch

The SAM riboswitch seed alignment has been revised using the 3D structure information View family →

manA RNA

The manA seed alignment has been revised using the original ZWD alignment View family →

L4-Archaeoglobi

L4-Archaeoglobi is one of the new r-leader families imported from ZWD View family →

General Flavivirus xrRNA

General Flavivirus exoribonuclease-resistant RNA element is one of the new Flavivirus RNA families View family →

LOOT RNA

LOOT RNA has been imported from ZWD View family →

Alphacoronavirus 5' UTR

Alphacoronavirus 5' UTR includes SL1, SL2, SL4, and SL5 stem loops View family →