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Browse ZNHIT6

Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF04438 HIT zinc finger
Function

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.

> Gene Ontology
 
Biological Process GO:0000491 small nucleolar ribonucleoprotein complex assembly
GO:0000492 box C/D snoRNP assembly
GO:0006403 RNA localization
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0042254 ribosome biogenesis
GO:0048254 snoRNA localization
GO:0051259 protein oligomerization
GO:0071826 ribonucleoprotein complex subunit organization
Molecular Function GO:0001085 RNA polymerase II transcription factor binding
GO:0001091 RNA polymerase II basal transcription factor binding
GO:0001094 TFIID-class transcription factor binding
GO:0001098 basal transcription machinery binding
GO:0001099 basal RNA polymerase II transcription machinery binding
GO:0008134 transcription factor binding
GO:0051117 ATPase binding
Cellular Component GO:0070761 pre-snoRNP complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ZNHIT6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ZNHIT6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ZNHIT6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1510.551
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5550.686
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1450.887
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7320.0246
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.450.814
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.0950.619
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1340.7
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0170.991
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2830.863
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7480.477
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2130.429
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0270.754
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZNHIT6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZNHIT6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZNHIT6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZNHIT6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ZNHIT6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ZNHIT6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolZNHIT6
Namezinc finger, HIT-type containing 6
Aliases FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ......
Chromosomal Location1p22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ZNHIT6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.