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Browse XBP1

Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). ; SUBCELLULAR LOCATION: Isoform 1: Nucleus Cytoplasm Endoplasmic reticulum membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Peripheral membrane protein Membrane Peripheral membrane protein Note=Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (PubMed:19394296, PubMed:25190803). ; SUBCELLULAR LOCATION: Isoform 2: Nucleus Cytoplasm Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity). ; SUBCELLULAR LOCATION: X-box-binding protein 1, cytoplasmic form: Cytoplasm Nucleus Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (PubMed:25239945).
Domain PF07716 Basic region leucine zipper
Function

Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). ; FUNCTION: Isoform 1: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ENR1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production (PubMed:19394296, PubMed:21233347). In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis (PubMed:23529610). Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway (PubMed:16461360, PubMed:25239945). Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor (PubMed:8657566). Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress (PubMed:25190803). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences (PubMed:8657566). Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) (PubMed:2321018, PubMed:2196176, PubMed:1903538, PubMed:8657566). Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner (PubMed:25190803). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). ; FUNCTION: Isoform 2: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610). Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933). Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941). Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803). Binds to the BECN1 gene promoter region (PubMed:23184933). Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856). Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464). Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity).

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001525 angiogenesis
GO:0001678 cellular glucose homeostasis
GO:0001819 positive regulation of cytokine production
GO:0001889 liver development
GO:0001935 endothelial cell proliferation
GO:0002064 epithelial cell development
GO:0002070 epithelial cell maturation
GO:0002237 response to molecule of bacterial origin
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002313 mature B cell differentiation involved in immune response
GO:0002317 plasma cell differentiation
GO:0002335 mature B cell differentiation
GO:0002366 leukocyte activation involved in immune response
GO:0002377 immunoglobulin production
GO:0002440 production of molecular mediator of immune response
GO:0002521 leukocyte differentiation
GO:0002637 regulation of immunoglobulin production
GO:0002639 positive regulation of immunoglobulin production
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002702 positive regulation of production of molecular mediator of immune response
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006914 autophagy
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0007159 leukocyte cell-cell adhesion
GO:0007431 salivary gland development
GO:0007517 muscle organ development
GO:0007584 response to nutrient
GO:0007589 body fluid secretion
GO:0007595 lactation
GO:0009267 cellular response to starvation
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009750 response to fructose
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010498 proteasomal protein catabolic process
GO:0010506 regulation of autophagy
GO:0010830 regulation of myotube differentiation
GO:0010832 negative regulation of myotube differentiation
GO:0014902 myotube differentiation
GO:0016053 organic acid biosynthetic process
GO:0021700 developmental maturation
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022612 gland morphogenesis
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031016 pancreas development
GO:0031017 exocrine pancreas development
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031670 cellular response to nutrient
GO:0032496 response to lipopolysaccharide
GO:0032635 interleukin-6 production
GO:0032675 regulation of interleukin-6 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032941 secretion by tissue
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035272 exocrine system development
GO:0035356 cellular triglyceride homeostasis
GO:0035470 positive regulation of vascular wound healing
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036498 IRE1-mediated unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0040017 positive regulation of locomotion
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042149 cellular response to glucose starvation
GO:0042176 regulation of protein catabolic process
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0042632 cholesterol homeostasis
GO:0042692 muscle cell differentiation
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0044283 small molecule biosynthetic process
GO:0045342 MHC class II biosynthetic process
GO:0045346 regulation of MHC class II biosynthetic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045444 fat cell differentiation
GO:0045577 regulation of B cell differentiation
GO:0045579 positive regulation of B cell differentiation
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045862 positive regulation of proteolysis
GO:0046394 carboxylic acid biosynthetic process
GO:0048305 immunoglobulin secretion
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048732 gland development
GO:0050663 cytokine secretion
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050863 regulation of T cell activation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0050878 regulation of body fluid levels
GO:0051023 regulation of immunoglobulin secretion
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051047 positive regulation of secretion
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051222 positive regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051272 positive regulation of cellular component movement
GO:0055088 lipid homeostasis
GO:0055089 fatty acid homeostasis
GO:0055090 acylglycerol homeostasis
GO:0055092 sterol homeostasis
GO:0055123 digestive system development
GO:0060055 angiogenesis involved in wound healing
GO:0060612 adipose tissue development
GO:0060689 cell differentiation involved in salivary gland development
GO:0060690 epithelial cell differentiation involved in salivary gland development
GO:0060691 epithelial cell maturation involved in salivary gland development
GO:0061008 hepaticobiliary system development
GO:0061041 regulation of wound healing
GO:0061042 vascular wound healing
GO:0061043 regulation of vascular wound healing
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061448 connective tissue development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070328 triglyceride homeostasis
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070670 response to interleukin-4
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071229 cellular response to acid chemical
GO:0071230 cellular response to amino acid stimulus
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071353 cellular response to interleukin-4
GO:0071375 cellular response to peptide hormone stimulus
GO:0071396 cellular response to lipid
GO:0071417 cellular response to organonitrogen compound
GO:0071496 cellular response to external stimulus
GO:0071593 lymphocyte aggregation
GO:0072330 monocarboxylic acid biosynthetic process
GO:0072574 hepatocyte proliferation
GO:0072575 epithelial cell proliferation involved in liver morphogenesis
GO:0072576 liver morphogenesis
GO:0072604 interleukin-6 secretion
GO:0090303 positive regulation of wound healing
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900098 regulation of plasma cell differentiation
GO:1900100 positive regulation of plasma cell differentiation
GO:1900101 regulation of endoplasmic reticulum unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901342 regulation of vasculature development
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1903034 regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903487 regulation of lactation
GO:1903489 positive regulation of lactation
GO:1903532 positive regulation of secretion by cell
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1904018 positive regulation of vasculature development
GO:1904951 positive regulation of establishment of protein localization
GO:1990418 response to insulin-like growth factor stimulus
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
GO:2000345 regulation of hepatocyte proliferation
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000778 positive regulation of interleukin-6 secretion
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0001047 core promoter binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0008134 transcription factor binding
GO:0035326 enhancer binding
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042826 histone deacetylase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046982 protein heterodimerization activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome R-HSA-381183: ATF6 (ATF6-alpha) activates chaperone genes
R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-392499: Metabolism of proteins
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-381038: XBP1(S) activates chaperone genes
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between XBP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between XBP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26073941Ovarian CarcinomaInhibit immunity (T cell function)Dendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer immunity. However, tumors often evade immune control by crippling normal DC function. Here we show that constitutive activation of XBP1 in tumor-associated DCs (tDCs) drives ovarian cancer (OvCa) progression by blunting anti-tumor immunity.
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of XBP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of XBP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4050.216
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2720.929
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4980.819
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2450.494
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0580.982
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4840.884
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0360.941
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2270.914
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2030.93
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1970.926
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1110.973
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0350.755
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of XBP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XBP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XBP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XBP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XBP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of XBP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between XBP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolXBP1
NameX-box binding protein 1
Aliases XBP2; TREB-5; TREB5; XBP-1; tax-responsive element-binding protein 5; X-box-binding protein 1
Chromosomal Location22q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting XBP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.