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Browse WAC

Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus speckle Nucleus Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
Domain PF00397 WW domain
Function

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877).

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0006513 protein monoubiquitination
GO:0006914 autophagy
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0010390 histone monoubiquitination
GO:0010498 proteasomal protein catabolic process
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0016236 macroautophagy
GO:0016239 positive regulation of macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016570 histone modification
GO:0016574 histone ubiquitination
GO:0031329 regulation of cellular catabolic process
GO:0031330 negative regulation of cellular catabolic process
GO:0031570 DNA integrity checkpoint
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033523 histone H2B ubiquitination
GO:0042176 regulation of protein catabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044783 G1 DNA damage checkpoint
GO:0045861 negative regulation of proteolysis
GO:0061136 regulation of proteasomal protein catabolic process
GO:0071894 histone H2B conserved C-terminal lysine ubiquitination
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1903362 regulation of cellular protein catabolic process
GO:1903363 negative regulation of cellular protein catabolic process
Molecular Function GO:0000993 RNA polymerase II core binding
GO:0001098 basal transcription machinery binding
GO:0001099 basal RNA polymerase II transcription machinery binding
GO:0003682 chromatin binding
GO:0043175 RNA polymerase core enzyme binding
GO:0070063 RNA polymerase binding
Cellular Component GO:0005681 spliceosomal complex
GO:0016604 nuclear body
GO:0016607 nuclear speck
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-8866654: E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8852135: Protein ubiquitination
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between WAC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of WAC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.65 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of WAC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.090.698
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3420.874
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0910.953
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0370.926
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.320.893
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.490.875
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1620.71
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3880.847
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1070.962
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.060.97
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6430.785
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0620.325
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of WAC in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916025-250.26
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59033.3-33.30.258
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WAC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WAC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WAC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WAC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of WAC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between WAC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolWAC
NameWW domain containing adaptor with coiled-coil
Aliases FLJ31290; PRO1741; BM-016; MGC10753; WW domain-containing adaptor with coiled coil; WW domain-containing ada ......
Chromosomal Location10p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting WAC collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.