[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse VPS8

Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Early endosome
Domain PF12816 Golgi CORVET complex core vacuolar protein 8
Function

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).

> Gene Ontology
 
Biological Process GO:0006906 vesicle fusion
GO:0016050 vesicle organization
GO:0034058 endosomal vesicle fusion
GO:0044801 single-organism membrane fusion
GO:0048284 organelle fusion
GO:0061025 membrane fusion
GO:0090174 organelle membrane fusion
Molecular Function -
Cellular Component GO:0005769 early endosome
GO:0033263 CORVET complex
GO:0044440 endosomal part
GO:0099023 tethring complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between VPS8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of VPS8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.63 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of VPS8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2680.234
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8440.521
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1560.88
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.220.478
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.420.846
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0310.991
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.080.814
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0080.996
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1830.918
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4190.756
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0790.567
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0560.165
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of VPS8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.118.8-7.71
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472528.6-3.61
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of VPS8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between VPS8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolVPS8
Namevacuolar protein sorting 8 homolog (S. cerevisiae)
Aliases FLJ32099; KIAA0804; Vacuolar protein sorting-associated protein 8 homolog
Chromosomal Location3q27.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting VPS8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.