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Browse TWF1

Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).
Domain PF00241 Cofilin/tropomyosin-type actin-binding protein
Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).

> Gene Ontology
 
Biological Process GO:0007015 actin filament organization
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0010639 negative regulation of organelle organization
GO:0030041 actin filament polymerization
GO:0030042 actin filament depolymerization
GO:0030047 actin modification
GO:0030832 regulation of actin filament length
GO:0030833 regulation of actin filament polymerization
GO:0030834 regulation of actin filament depolymerization
GO:0030835 negative regulation of actin filament depolymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0031289 actin phosphorylation
GO:0031333 negative regulation of protein complex assembly
GO:0032271 regulation of protein polymerization
GO:0032272 negative regulation of protein polymerization
GO:0032507 maintenance of protein location in cell
GO:0032535 regulation of cellular component size
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0032984 macromolecular complex disassembly
GO:0042989 sequestering of actin monomers
GO:0043241 protein complex disassembly
GO:0043242 negative regulation of protein complex disassembly
GO:0043244 regulation of protein complex disassembly
GO:0043254 regulation of protein complex assembly
GO:0043538 regulation of actin phosphorylation
GO:0043624 cellular protein complex disassembly
GO:0045185 maintenance of protein location
GO:0051016 barbed-end actin filament capping
GO:0051235 maintenance of location
GO:0051258 protein polymerization
GO:0051261 protein depolymerization
GO:0051493 regulation of cytoskeleton organization
GO:0051494 negative regulation of cytoskeleton organization
GO:0051651 maintenance of location in cell
GO:0051693 actin filament capping
GO:0090066 regulation of anatomical structure size
GO:1901879 regulation of protein depolymerization
GO:1901880 negative regulation of protein depolymerization
Molecular Function GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005543 phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0035091 phosphatidylinositol binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:1901981 phosphatidylinositol phosphate binding
GO:1902936 phosphatidylinositol bisphosphate binding
Cellular Component GO:0001726 ruffle
GO:0005913 cell-cell adherens junction
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0030055 cell-substrate junction
GO:0030175 filopodium
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032587 ruffle membrane
GO:0043292 contractile fiber
GO:0098858 actin-based cell projection
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TWF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TWF1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28783722MelanomaPromote immunity (T cell function)Fifteen genes showed significant resistance to T-cell-mediated cytolysis with at least 1 sgRNA in these cells.; MART-1+ Mel624 cells with sgRNAs targeting each of the 9 candidate genes showed increased resistance against these T cells (Extended Data Fig. 6b, P < 0.05). The genes that we validated across different melanoma cell lines and different antigen–TCR combinations include cellular cytoskeleton genes, COL17A1 (collagen type XVII alpha 1) and TWF1 (twinfilin-1), a microRNA (hsa-mir-101-2) and a 60S ribosomal subunit (RPL23, Supplementary Discussion).
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TWF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TWF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2440.458
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0050.998
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4320.792
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1180.73
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3070.859
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1210.956
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0910.86
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0830.967
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2890.897
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0240.987
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4030.86
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.080.31
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TWF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TWF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TWF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TWF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TWF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TWF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TWF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTWF1
Nametwinfilin actin binding protein 1
Aliases PTK9; protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin, actin-binding protein, homolog 1 ......
Chromosomal Location12q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TWF1 collected from DrugBank database.
> Drugs from DrugBank database
 

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