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Browse TRAT1

Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type III membrane protein
Domain -
Function

Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.

> Gene Ontology
 
Biological Process GO:0001881 receptor recycling
GO:0001919 regulation of receptor recycling
GO:0001920 negative regulation of receptor recycling
GO:0002250 adaptive immune response
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006968 cellular defense response
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0030258 lipid modification
GO:0043112 receptor metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0050848 regulation of calcium-mediated signaling
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0050854 regulation of antigen receptor-mediated signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051051 negative regulation of transport
Molecular Function GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0030674 protein binding, bridging
GO:0030971 receptor tyrosine kinase binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035591 signaling adaptor activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:0060090 binding, bridging
GO:1990782 protein tyrosine kinase binding
Cellular Component GO:0042101 T cell receptor complex
GO:0043235 receptor complex
GO:0098802 plasma membrane receptor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-202424: Downstream TCR signaling
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-180292: GAB1 signalosome
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-202403: TCR signaling
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TRAT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TRAT1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TRAT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.020.962
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.090.901
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0280.962
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1730.749
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4470.627
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1720.869
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.8970.158
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.1650.206
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5180.601
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.8380.0208
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5470.193
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.020.937
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TRAT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRAT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRAT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRAT1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRAT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TRAT1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TRAT1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTRAT1
NameT cell receptor associated transmembrane adaptor 1
Aliases HSPC062; TRIM; TCRIM; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell rec ......
Chromosomal Location3q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TRAT1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.