TISIDB

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass type I membrane protein
Domain	PF00041 Fibronectin type III domain PF00047 Immunoglobulin domain PF07714 Protein tyrosine kinase
Function	Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

> Gene Ontology [ TOP ]
Biological Process	GO:0001101 response to acid chemical GO:0001525 angiogenesis GO:0001570 vasculogenesis GO:0001701 in utero embryonic development GO:0007498 mesoderm development GO:0016525 negative regulation of angiogenesis GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030336 negative regulation of cell migration GO:0032526 response to retinoic acid GO:0040013 negative regulation of locomotion GO:0044801 single-organism membrane fusion GO:0045026 plasma membrane fusion GO:0045765 regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0051271 negative regulation of cellular component movement GO:0061025 membrane fusion GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:2000146 negative regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis
Molecular Function	GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0019199 transmembrane receptor protein kinase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TIE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of TIE1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of TIE1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.874	0.0327
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.517	0.713
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1.121	0.2
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.321	0.348
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.373	0.857
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.261	0.916
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.318	0.515
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.393	0.721
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.173	0.893
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.655	0.659
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.845	0.349
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.376	0.00365

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of TIE1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	5.9	1.2	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	6.8	0.6	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	6.8	0.6	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	22.2	0	22.2	0.12
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	7.4	0.5	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	15.4	-6.3	0.618
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TIE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TIE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TIE1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TIE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TIE1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TIE1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TIE1
Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Aliases	JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine-pro ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TIE1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse TIE1