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Browse STX3

Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type IV membrane protein
Domain PF05739 SNARE domain
PF00804 Syntaxin
Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0006906 vesicle fusion
GO:0007009 plasma membrane organization
GO:0007269 neurotransmitter secretion
GO:0016050 vesicle organization
GO:0016079 synaptic vesicle exocytosis
GO:0016081 synaptic vesicle docking
GO:0017156 calcium ion regulated exocytosis
GO:0022406 membrane docking
GO:0023061 signal release
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane
GO:0032103 positive regulation of response to external stimulus
GO:0034394 protein localization to cell surface
GO:0040017 positive regulation of locomotion
GO:0044801 single-organism membrane fusion
GO:0045026 plasma membrane fusion
GO:0045055 regulated exocytosis
GO:0045785 positive regulation of cell adhesion
GO:0048167 regulation of synaptic plasticity
GO:0048278 vesicle docking
GO:0048284 organelle fusion
GO:0048489 synaptic vesicle transport
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0060291 long-term synaptic potentiation
GO:0061025 membrane fusion
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090174 organelle membrane fusion
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0099003 vesicle-mediated transport in synapse
GO:0099500 vesicle fusion to plasma membrane
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1903076 regulation of protein localization to plasma membrane
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903729 regulation of plasma membrane organization
GO:1903829 positive regulation of cellular protein localization
GO:1904375 regulation of protein localization to cell periphery
GO:1904377 positive regulation of protein localization to cell periphery
GO:1990778 protein localization to cell periphery
GO:2000008 regulation of protein localization to cell surface
GO:2000010 positive regulation of protein localization to cell surface
Molecular Function GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005504 fatty acid binding
GO:0031406 carboxylic acid binding
GO:0033293 monocarboxylic acid binding
GO:0036041 long-chain fatty acid binding
GO:0043168 anion binding
GO:0050542 icosanoid binding
GO:0050543 icosatetraenoic acid binding
GO:0050544 arachidonic acid binding
Cellular Component GO:0005766 primary lysosome
GO:0008021 synaptic vesicle
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030133 transport vesicle
GO:0030141 secretory granule
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031201 SNARE complex
GO:0031252 cell leading edge
GO:0033267 axon part
GO:0042470 melanosome
GO:0042581 specific granule
GO:0042582 azurophil granule
GO:0042588 zymogen granule
GO:0042589 zymogen granule membrane
GO:0042734 presynaptic membrane
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0044306 neuron projection terminus
GO:0045177 apical part of cell
GO:0048770 pigment granule
GO:0070382 exocytic vesicle
GO:0097060 synaptic membrane
GO:0097470 ribbon synapse
GO:0098793 presynapse
GO:0099503 secretory vesicle
GO:1990796 photoreceptor cell terminal bouton
> KEGG and Reactome Pathway
 
KEGG hsa04130 SNARE interactions in vesicular transport
hsa04721 Synaptic vesicle cycle
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-449147: Signaling by Interleukins
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STX3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STX3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STX3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.8210.0167
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.6620.315
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2070.866
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.070.829
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0330.989
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2030.946
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2520.55
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2870.876
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1780.928
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3890.797
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0070.998
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0080.94
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STX3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STX3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STX3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STX3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STX3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STX3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STX3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTX3
Namesyntaxin 3
Aliases STX3A; syntaxin 3A; Syntaxin-3
Chromosomal Location11q12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STX3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.