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Browse STK38

Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm.
Domain PF00069 Protein kinase domain
PF00433 Protein kinase C terminal domain
Function

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0033673 negative regulation of kinase activity
GO:0042326 negative regulation of phosphorylation
GO:0043405 regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0051348 negative regulation of transferase activity
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:1902532 negative regulation of intracellular signal transduction
Molecular Function GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
GO:0034708 methyltransferase complex
GO:0035097 histone methyltransferase complex
GO:0070688 MLL5-L complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STK38 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STK38 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.73 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STK38 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0290.9
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1350.942
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0470.972
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2620.455
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1890.925
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3570.89
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1180.751
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.390.817
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1790.924
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.660.638
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0170.617
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1470.0285
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STK38 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 1417011.8-11.80.488
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414014.3-14.31
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STK38. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STK38. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STK38.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STK38. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STK38 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STK38 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTK38
Nameserine/threonine kinase 38
Aliases NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ......
Chromosomal Location6p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STK38 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.