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Browse SRGAP2C

Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00611 Fes/CIP4
Function

Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0008347 glial cell migration
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021795 cerebral cortex cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021801 cerebral cortex radial glia guided migration
GO:0021814 cell motility involved in cerebral cortex radial glia guided migration
GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
GO:0021885 forebrain cell migration
GO:0021987 cerebral cortex development
GO:0022029 telencephalon cell migration
GO:0022030 telencephalon glial cell migration
GO:0030031 cell projection assembly
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030900 forebrain development
GO:0031268 pseudopodium organization
GO:0031269 pseudopodium assembly
GO:0031345 negative regulation of cell projection organization
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0042063 gliogenesis
GO:0045665 negative regulation of neuron differentiation
GO:0046847 filopodium assembly
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050773 regulation of dendrite development
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051489 regulation of filopodium assembly
GO:0051490 negative regulation of filopodium assembly
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0060491 regulation of cell projection assembly
GO:0060996 dendritic spine development
GO:0060998 regulation of dendritic spine development
GO:0061000 negative regulation of dendritic spine development
GO:2000146 negative regulation of cell motility
GO:2000147 positive regulation of cell motility
GO:2000171 negative regulation of dendrite development
GO:2001222 regulation of neuron migration
GO:2001224 positive regulation of neuron migration
Molecular Function GO:0005096 GTPase activator activity
GO:0008047 enzyme activator activity
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0046982 protein heterodimerization activity
GO:0048365 Rac GTPase binding
GO:0051020 GTPase binding
GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SRGAP2C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SRGAP2C in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SRGAP2C in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3650.612
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2940.321
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3310.735
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.240.66
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5430.556
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1340.898
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0050.988
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3210.809
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.410.768
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 482.0050.0298
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.80.0352
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1310.209
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SRGAP2C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SRGAP2C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SRGAP2C.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SRGAP2C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SRGAP2C expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SRGAP2C and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSRGAP2C
NameSLIT-ROBO Rho GTPase activating protein 2C
Aliases SRGAP2P1; SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1; SLIT-ROBO Rho GTPase-activating protein 2C
Chromosomal Location1p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SRGAP2C collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.