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Browse SNAP91

Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Membrane, coated pit Peripheral membrane protein Cytoplasmic side Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Domain PF07651 ANTH domain
Function

Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity).

> Gene Ontology
 
Biological Process GO:0006898 receptor-mediated endocytosis
GO:0030100 regulation of endocytosis
GO:0048259 regulation of receptor-mediated endocytosis
GO:0048268 clathrin coat assembly
GO:0060627 regulation of vesicle-mediated transport
GO:0072583 clathrin-dependent endocytosis
GO:2000369 regulation of clathrin-dependent endocytosis
Molecular Function GO:0005543 phospholipid binding
GO:0005545 1-phosphatidylinositol binding
GO:0030276 clathrin binding
GO:0035091 phosphatidylinositol binding
Cellular Component GO:0005905 clathrin-coated pit
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0098589 membrane region
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SNAP91 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SNAP91 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SNAP91 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1750.359
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.390.498
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0140.972
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3220.498
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7720.547
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2540.858
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.0310.236
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.2940.133
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2330.895
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0730.884
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0730.92
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.7790.0362
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SNAP91 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.86.880.247
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.88.56.30.453
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211728.611.816.80.257
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.818.212.60.649
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.311.1-5.80.642
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.515.4-10.90.541
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SNAP91. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SNAP91. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SNAP91.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SNAP91. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SNAP91 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SNAP91 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSNAP91
Namesynaptosomal-associated protein, 91kDa
Aliases KIAA0656; AP180; synaptosomal-associated protein, 91 kDa (mouse) homolog; synaptosomal-associated protein, 9 ......
Chromosomal Location6q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SNAP91 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.