[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse SMG1

Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm
Domain character(0) character(0)
PF02260 FATC domain
PF00454 Phosphatidylinositol 3- and 4-kinase
PF15785 Serine/threonine-protein kinase smg-1
Function

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

> Gene Ontology
 
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000723 telomere maintenance
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0006403 RNA localization
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006913 nucleocytoplasmic transport
GO:0015931 nucleobase-containing compound transport
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0019439 aromatic compound catabolic process
GO:0030258 lipid modification
GO:0032200 telomere organization
GO:0034655 nucleobase-containing compound catabolic process
GO:0044270 cellular nitrogen compound catabolic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046700 heterocycle catabolic process
GO:0046777 protein autophosphorylation
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0051028 mRNA transport
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051236 establishment of RNA localization
GO:0060249 anatomical structure homeostasis
GO:0071166 ribonucleoprotein complex localization
GO:0071426 ribonucleoprotein complex export from nucleus
GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus
GO:1901361 organic cyclic compound catabolic process
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0042162 telomeric DNA binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa03015 mRNA surveillance pathway
Reactome R-HSA-74160: Gene Expression
R-HSA-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-927802: Nonsense-Mediated Decay (NMD)
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SMG1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SMG1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 3.54; FDR: 0.046 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SMG1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1520.607
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0920.948
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3240.737
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1580.587
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1830.951
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1280.974
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2110.637
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2410.907
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1980.931
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0340.975
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8640.553
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0620.172
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SMG1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916018.8-18.80.28
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47028.6-28.60.491
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.37.4-2.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.515.4-10.90.541
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMG1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMG1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMG1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMG1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SMG1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SMG1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSMG1
NameSMG1 phosphatidylinositol 3-kinase-related kinase
Aliases KIAA0421; phosphatidylinositol 3-kinase-related kinase; smg-1 homolog, phosphatidylinositol 3-kinase-related ......
Chromosomal Location16p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SMG1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.